Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica

Page 19 of about 789 results

ea0071028 | Fertility in men with 5-alpha reductase deficiency | BES2020

Fertility in men with 5-alpha reductase deficiency

Wout Devlies , Elisabet Van Loon , Steven Joniau , Frank Claessens , Leen Antonio , Dirk Vanderschueren

Introduction: 5 Alpha reductase deficiency (5-ARD) is a rare autosomal recessive disorder causing disturbance of sex development. 5 Alpha reductase is an enzyme involved in steroid metabolism, catalyzing testosterone into dihydrotestosterone (DHT), its potent form. 5-ARD therefore results in lower DHT and higher testosterone values. DHT is crucial for the differentiation of the urogenital sinus and genital tubercle into the external genitalia, urethra and prostate, while the v...
3 shares

ea0073aep22 | Adrenal and Cardiovascular Endocrinology | ECE2021

Impact of adrenal insufficiency on female sexual function: A preliminary study

Zamponi Virginia , Mazzilli Rossella , Maggio Roberta , Lardo Pina , Olana Soraya , Pugliese Giuseppe , Faggiano Antongiulio , Stigliano Antonio

IntroductionAdrenal insufficiency is a clinical condition that leads to depletion of glucocorticoids, mineralocorticoids and androgens. While in men adrenal androgen deficiency is not clinically significant for testicular testosterone synthesis, in women so far androgen treatment is suggested for the reduction of libido and depression. However, no data is currently available on female sexual function.Primary endpoints<p class="...
1 shares

ea0073aep396 | Endocrine-Related Cancer | ECE2021

Parathyroid carcinoma: A case report

Jose Antonio Ariza Jimenez , Eyvee Arturo Cuellar Lloclla , Jose Alvaro Romero Porcel

IntroductionParathyroid carcinoma is a rare endocrine carcinoma, which represents less than 1% of all cases of primary hyperparathyroidism. It usually affects people between 44–55 years old without differences between sexes. Sometimes it is related to HRPT2 gene mutations and it has a variable prognosis.Presentation of caseA 56-year-old man was referred to our centre to complete an hypercalcemia study. H...
0 shares

ea0075m03 | Metabolic Bone | EYES2021

Management of a rare life-threatening parathyroid carcinoma

Zelano Lorenzo , Maggio Ettore , Veleno Miriam , Mura Chiara , Morgante Cesare , Antonio Rota Carlo , Pontecorvi Alfredo

Background: Parathyroid carcinoma (PC) is rare, usually presenting with hyperparathyroidism and severe hypercalcemia. A standardized diagnostic, prognostic and therapeutic approach has not been provided yet and TNM staging algorithm is not universally accepted. Surgery is the first-choice treatment and is the only effective therapy to control hypercalcaemia. Chemo- or radio-therapy, local treatments or novel drugs should be reserved to selected cases.Cas...
1 shares

ea0092ps1-06-04 | Thyroid Cancer clinical 1 | ETA2023

Predictive factors for central neck compartment lymphnodes metastases’ in sporadic medullary thyroid cancer patients

Cappagli Virginia , Matrone Antonio , Piaggi Paolo , Bottici Valeria , Agate Laura , Molinaro Eleonora , Torregrossa Liborio , Elisei Rossella

Introduction: Total thyroidectomy (TT) plus central neck compartment (CC) lymphnode dissection is still the recommended initial gold standard treatment for medullary thyroid cancer (MTC), even in the absence of a pre-surgical positive neck US evidence of lymphnode metastases. Considering the risk of surgical complications of this prophylactic surgery and the low rate of histologic finding of CC lymphnode metastases, a more tailored lymphnode’ surgery should be proposed. A...
0 shares

ea0092ps2-17-09 | Thyroid Cancer Diagnosis 2 | ETA2023

Clinical application of grading system in sporadic medullary thyroid carcinoma patients

Prete Alessandro , Torregrossa Liborio , Gambale Carla , Materazzi Gabriele , Elisei Rossella , Matrone Antonio

Introduction: Despite its neuroendocrine origin, only recently an international study group proposed a dedicated grading system (IMTCGS) for medullary thyroid carcinoma (MTC). IMTCGS is an independent and powerful tool able to predict disease specific survival (DSS) as well as distant metastasis-free (DMFS) and locoregional recurrence-free survivals (LRFS), regardless of other risk factors, including staging.Objectives: To evaluate the performance of IMT...
0 shares

ea0092ps3-27-02 | Thyroid Cancer clinical 3 | ETA2023

Central (N1A) and latero-cervical (N1B) lymph nodes metastases in sporadic medullary thyroid carcinoma patients: clinical impact on disease specific and recurrence free survival

Matrone Antonio , Prete Alessandro , Gambale Carla , Cappagli Virginia , Bottici Valeria , Materazzi Gabriele , Torregrossa Liborio , Elisei Rossella

Background: Distant metastases at diagnosis is the worst prognostic factor for disease specific survival (DSS) in sporadic medullary thyroid carcinoma (MTC). Also, lymph node metastases are negative prognostic factors both for DSS and recurrence free survival (RFS). The question whether central (N1a) and latero-cervical compartment lymph nodes metastasis (N1b), separately evaluated, can have a different impact on DSS and RFS remains to be clarified.Patie...
0 shares

ea0092ps3-28-02 | Translational 2 | ETA2023

Hypothesizing a role of ret hyperactivation on weight control in patients with type 2A multiple endocrine neoplasia (MEN2A)

Prete Alessandro , Gambale Carla , Piaggi Paolo , Romei Cristina , Cappagli Virginia , Bottici Valeria , Elisei Rossella , Matrone Antonio

Introduction: RET gene is responsible for various human cancers and is mutated and hyperactivated in nearly 100% of familial (germline mutation) and in about 60% of sporadic (somatic mutation) MTC cases. Moreover, RET gene play a role in several physiologic and pathologic conditions. Very recently, the hyperfunction of RET was found to be a key process in weight loss. The hypothesis is that in a peculiar population in which RET gene is mutated and constitutively activated from...
0 shares

ea0094p207 | Metabolism, Obesity and Diabetes | SFEBES2023

Vertical sleeve gastrectomy: Attenuating cortisol activation in mice and humans via pro-inflammatory cytokine reduction

Liang Shiyi , Wang Wenya , Samarasinghe Suhaniya , Riva Antonio , Miras Alexander , Akalestou Elina

Background: Cortisol is a hormone produced by the adrenal cortex and is essential for the maintenance of metabolic homeostasis. Cortisol activation is catalysed by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and excess cortisol is associated with insulin resistance and hyperglycaemia. Previous studies from our group have shown that Vertical Sleeve Gastrectomy, a gastrointestinal procedure known to improve insulin sensitivity, causes cortisol inhibi...
0 shares

ea0063cet1biog | Clinical Endocrinology Trust Lecture | ECE2019

Clinical Endocrinology Trust Award 2019 – Biography

Susan M. Webb was born and qualified from Medical School in Barcelona, Spain, and completed training at St. Bartholomew’s Hospital, London and in San Antonio, Texas. She is a Senior Consultant Endocrinologist at the Hospital Sant Pau, and Professor of Medicine at the Universitat Autònoma de Barcelona. She runs the Neuroendocrine Clinic and the Pituitary Disease network of excellence research group (CIBERER u...
0 shares

Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 | Privacy policy | Cookie settings

BiosciAbstracts

Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.

Find out more